Ray later used it during the battle against Tiamat. Ray and Peter used the Ecto-2 to lay cover fire on Murray the Mantis to prevent it from fleeing Central Park prematurely. Slimer lost control and the Ecto-2 plummeted into the river below.

Slimer took the co-pilot seat and was instructed with blasting certain clouds with Silver Iodide to influence a rainstorm and draw out Simon Quegg's Horse and Buggy and the Dark Rider. It now more closely resembled its original design. The Ecto-2 was piloted by Egon during the Simon Quegg case. While they pursued the Crimelord, the thrower was disabled. Like the rest of the equipment, the thrower was attuned to people's bio-electric field. It had an enclosed cockpit, seating for four, and a Particle Thrower mounted on the roof at the base of the rotor. Since they were making more money than they could spend, the Ecto-2 was upgraded. The Ecto-2 was rebuilt and later refurbished when the Ghostbusters were briefly the Crimebusters. Egon set it to full power overload and the resulting ectoplasmic explosion dispersed the entity while not harming anything else in the nearby vicinity. The Ecto-2 was once sacrificed to disperse the Toy Ghost. The usual pilot of the Ecto-2 became Winston Zeddemore. He also flew it when having to deal with a dragon an ancestor, Zedikiah Spengler, dealt with and when the gang became the Crimebusters. He managed to do so without taking any flying lessons. The first Ghostbuster known to fly the Ecto-2 was Egon Spengler. The Ecto-2 can be stored inside the back of the Ecto-1 or on a helipad atop the Firehouse. The Ecto-2 is an aerial vehicle used from time to time by the Ghostbusters.

2016 ghostbusters ecto 1